Author:
El Hajj Cynthia,Walrand Stéphane,Helou Mariana,Yammine Kaissar
Abstract
Background: A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon. Methods: Non-Obese patients with T2DM (n = 88), deficient/insufficient in vitamin D, were randomly assigned into one of two groups—a treatment group receiving 30,000 IU cholecalciferol/week for a period of six months, and a placebo group. Serum concentrations of TNF-α, high-sensitivity C-reactive protein (hs-CRP), and Interleukin-6 (IL-6) were the primary outcomes. A homeostatic model of insulin resistance (HOMA-IR) was assessed, in addition to serum concentrations of fasting blood glucose (FBG), HbA1C, (25(OH) D), and PTH. Results: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-α concentrations (p < 0.0001) compared to placebo. The decrease perceived in IL-6 concentrations was not significant (p = 0.1). No significant changes were seen in FBG (p = 0.9) and HbA1c levels (p = 0.85). Conclusion: Six months of vitamin D supplementation led to a decrease in some inflammatory markers in patients with T2DM. Additional studies with a larger sample and a longer period are advised in this regard. This trial was registered at ClinicalTrial.gov; Identifier number: NCT 03782805.
Subject
Food Science,Nutrition and Dietetics
Reference55 articles.
1. Expression of 25-hydroxyvitamin D3-1$alpha;-hydroxylase in pancreatic islets*1
2. Vitamin D deficiency among the healthy population in Lebanon;Khalife;World J. Pharm. Pharm. Sci.,2017
3. Vitanim D Status in Middle East and Africa;El-Rassi,2009
4. International Diabetes Federation: IDF Diabetes Atlas
https://www.diabetesatlas.org/upload/resources/2019/IDFAtlas9th_Edition_2019.pdf
5. Inflammasomes and type 2 diabetes: An updated systematic review
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献