Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study

Author:

Lin Wei-De,Ou Chu-Chyn,Hsiao Shih-Hao,Chang Chih-Han,Tsai Fuu-Jen,Liao Jiunn-WangORCID,Chen Yng-Tay

Abstract

Acrylamide (ACR), which is formed during the Maillard reaction, is used in various industrial processes. ACR accumulation in humans and laboratory animals results in genotoxicity, carcinogenicity, neurotoxicity, and reproductive toxicity. In this study, we investigated the mechanisms by which ACR may induce vasorelaxation and neuromuscular toxicity. Vasorelaxation was studied using an isolated rat aortic ring model. The aortic rings were divided into the following groups: with or without endothelium, with nitric oxide synthase (NOS) inhibition, with acetylcholine receptor inhibition, and with extracellular calcium inhibition. Changes in tension were used to indicate vasorelaxation. Neuromuscular toxicity was assessed using a phrenic nerve–diaphragm model. Changes in muscle contraction stimulated by the phrenic nerve were used to indicate neuromuscular toxicity. ACR induced the vasorelaxation of phenylephrine-precontracted aortic rings, which could be significantly attenuated by NOS inhibitors. The results of the phrenic nerve–diaphragm experiments revealed that ACR reduced muscle stimulation and contraction through nicotinic acetylcholine receptor (AChR). ACR-induced vasotoxicity was regulated by NOS through the aortic endothelium. Nicotinic AChR regulated ACR-induced neuromuscular blockage.

Funder

China Medical University Hospital

National Chung-Hsing University

Ministry of Science and Technology, Taiwan

Publisher

MDPI AG

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology

Reference51 articles.

1. A Review on Acrylamide in Food: Occurrence, Toxicity, and Mitigation Strategies

2. NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of acrylamide

3. Acrylamide neurotoxicity

4. A Review of the Toxicology of Acrylamide

5. Oral supplements of combined fructo-and xylo-oligosaccharides during perinatal period significantly offsets acrylamide-induced oxidative impairments and neurotoxicity in rats;Krishna;J. Physiol. Pharmacol.,2018

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