Statistical Approaches in the Studies Assessing Associations between Human Milk Immune Composition and Allergic Diseases: A Scoping Review

Author:

Blyuss Oleg,Cheung Ka Yan,Chen Jessica,Parr Callum,Petrou Loukia,Komarova Alina,Kokina Maria,Luzan Polina,Pasko Egor,Eremeeva Alina,Peshko Dmitrii,Eliseev Vladimir I.,Pedersen Sindre AndreORCID,Azad Meghan B.ORCID,Jarvinen Kirsi M.,Peroni Diego G.ORCID,Verhasselt ValerieORCID,Boyle Robert J.ORCID,Warner John O.ORCID,Simpson Melanie R.ORCID,Munblit DanielORCID

Abstract

A growing number of studies are focusing on the associations between human milk (HM) immunological composition and allergic diseases. This scoping review aims to identify statistical methods applied in the field and highlight pitfalls and unmet needs. A comprehensive literature search in MEDLINE and Embase retrieved 13,607 unique records. Following title/abstract screening, 29 studies met the selection criteria and were included in this review. We found that definitions of colostrum and mature milk varied across the studies. A total of 17 out of 29 (59%) studies collected samples longitudinally, but only 12% of these used serial (longitudinal) analyses. Multivariable analysis was used in 45% of the studies, but statistical approaches to modelling varied largely across the studies. Types of variables included as potential confounding factors differed considerably between models. Discrimination analysis was absent from all studies and only a single study reported classification measures. Outcomes of this scoping review highlight lack of standardization, both in data collection and handling, which remains one of the main challenges in the field. Improved standardization could be obtained by a consensus group of researchers and clinicians that could recommend appropriate methods to be applied in future prospective studies, as well as already existing datasets.

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Diversity and trends of human milk banking: a scoping review from 1946 to 2021;Archives of Disease in Childhood - Fetal and Neonatal Edition;2022-10-07

2. Early nutrition and the development of allergic diseases;Early Nutrition and Long-Term Health;2022

3. Non-Coding RNAs in Human Breast Milk: A Systematic Review;Frontiers in Immunology;2021-09-01

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