Curcumin, Hormesis and the Nervous System

Author:

Concetta Scuto MariaORCID,Mancuso Cesare,Tomasello BarbaraORCID,Laura Ontario Maria,Cavallaro Andrea,Frasca Francesco,Maiolino Luigi,Trovato Salinaro Angela,Calabrese Edward J.,Calabrese VittorioORCID

Abstract

Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn (family Zingiberaceae) commonly used as a spice to color and flavor food. Several preclinical studies have suggested beneficial roles for curcumin as an adjuvant therapy in free radical-based diseases, mainly neurodegenerative disorders. Indeed, curcumin belongs to the family of hormetins and the enhancement of the cell stress response, mainly the heme oxygenase-1 system, is actually considered the common denominator for this dual response. However, evidence-based medicine has clearly demonstrated the lack of any therapeutic effect of curcumin to contrast the onset or progression of neurodegeneration and related diseases. Finally, the curcumin safety profile imposes a careful analysis of the risk/benefit balance prior to proposing chronic supplementation with curcumin.

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

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