Potential Effects of Oral Isotretinoin on Growth Plate and Height

Author:

Cardoso-Demartini Adriane A.1,Boguszewski Cesar Luiz2ORCID,Boguszewski Margaret C. S.3ORCID

Affiliation:

1. Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba 80060-240, PR, Brazil

2. Department of Internal Medicine, Endocrine Division (SEMPR), Hospital de Clínicas, Universidade Federal do Paraná, Curitiba 80030-110, PR, Brazil

3. Department of Pediatrics, Universidade Federal do Paraná, Curitiba 80030-110, PR, Brazil

Abstract

Longitudinal growth and puberty are the result of a complex interaction of genetic, hormonal, nutritional, and environmental factors. Acne vulgaris is a chronic disease of the pilosebaceous unit that affects 85% of adolescents worldwide. Isotretinoin is a synthetic vitamin A derivative drug effective and is widely employed for the treatment of moderate and severe acne vulgaris. Premature epiphyseal closure has been reported in patients with neuroblastoma treated with high doses of isotretinoin as well as in patients with acne receiving lower doses. Although the mechanisms for these effects are not clear, it has been suggested that isotretinoin may have a negative impact on the GH-IGF-I axis, leading to a reduction in IGF-I and IGFBP3 serum levels. Although many of the isotretinoin adverse effects in pediatric patients are transient, premature epiphyseal closure and bone abnormalities can lead to transient abnormalities and permanent deformities with a negative impact on longitudinal growth and final height. The aim of this study was to review the potential effects of oral isotretinoin on the growth plate and growth during childhood and adolescence.

Publisher

MDPI AG

Subject

General Medicine

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