Affiliation:
1. Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL 35899, USA
Abstract
Most patients with non-alcoholic steatohepatitis (NASH) have insulin resistance, and there is a near-universal association between NASH and insulin resistance. Insulin resistance induces lipid accumulation in the liver, leading to the development of metabolic syndrome. However, most NASH rodent models fail to develop metabolic syndrome. LEW.1WR1 rats that are 23 weeks old showed increased body mass, epididymal fat, and liver mass, suggesting obesity-driven metabolic dysfunction. We have characterized steatosis, inflammation, Mallory–Denk body formation with hematoxylin and eosin (H&E), and fibrosis with Trichome blue staining. The presence of hepatic fibrosis with other features of NASH described above is one of the major strengths of this model since most of the currently available NASH models do not develop microvesicular steatosis or fibrosis. Together with the other important features of NASH described above, we confirm that male LEW.1WR1 rats develop NASH and insulin resistance with a standard diet.
Funder
The University of Alabama in Huntsville, the Louis Stokes Alliance for Minority Participation
American Association of University Women
Reference58 articles.
1. Health and Economic Burden of Nonalcoholic Fatty Liver Disease in the United States and Its Impact on Veterans;Shetty;Fed. Pract.,2019
2. Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the Period 2016–2030;Estes;J. Hepatol.,2018
3. Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: A Review of Shared Cardiometabolic Risk Factors;Peng;Hypertension,2022
4. The Multiple-Hit Pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD);Buzzetti;Metabolism,2016
5. Mitochondrial Adaptations and Dysfunctions in Nonalcoholic Fatty Liver Disease;Begriche;Hepatology,2013
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