Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Neonatal Lung Disease: Tiny Particles, Major Promise, Rigorous Requirements for Clinical Translation

Author:

Lesage FloreORCID,Thébaud Bernard

Abstract

Extreme preterm birth disrupts late lung development and puts newborns at risk of developing chronic lung disease, known as bronchopulmonary dysplasia (BPD). BPD can be associated with life-long complications, and currently no effective treatment is available. Cell therapies are entering the clinics to curb complications of extreme preterm birth with several clinical trials testing the feasibility, safety and efficacy of mesenchymal stromal cells (MSCs). The therapeutic effect of MSCs is contained in their secretome, and nanosized membranous structures released by the MSCs, known as extracellular vesicles (EVs), have been shown to be the therapeutic vectors. Driven by this discovery, the efficacy of EV-based therapy is currently being explored in models of BPD. EVs derived from MSCs, contain a rich cargo of anti-inflammatory and pro-angiogenic molecules, making them suitable candidates to treat multifactorial diseases such as BPD. Here, we review the state-of-the-art of preclinical studies involving MSC-derived EVs in models of BPD and highlight technical and regulatory challenges that need to be addressed before clinical translation. In addition, we aim at increasing awareness regarding the importance of rigorous reporting of experimental details of EV experiments and to increase the outreach of the current established guidelines amongst researchers in the BPD field.

Publisher

MDPI AG

Subject

General Medicine

Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Stem cell-derived extracellular vesicles: a potential intervention for Bronchopulmonary Dysplasia;Pediatric Research;2024-09-09

2. Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023;American Journal of Physiology-Lung Cellular and Molecular Physiology;2024-09-01

3. Cell Therapies for Acute Radiation Syndrome;International Journal of Molecular Sciences;2024-06-26

4. Optimizing mesenchymal stem cell extracellular vesicles for chronic wound healing: Bioengineering, standardization, and safety;Regenerative Therapy;2024-06

5. The emerging role of extracellular vesicles in bronchopulmonary dysplasia;American Journal of Physiology-Lung Cellular and Molecular Physiology;2024-05-01

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