Phytochemistry, Antioxidant Potential, and Antibacterial Activities of Anacyclus pyrethrum: Promising Bioactive Compounds

Author:

Baslam Abdelmounaim1ORCID,Aitbaba Abdelfatah1ORCID,Aboufatima Rachida2,Agouram Fatimazahra1,Boussaa Samia3ORCID,Chait Abderrahman1ORCID,Baslam Marouane456ORCID

Affiliation:

1. Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco

2. Laboratory of Biological Engineering, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni Mellal 23000, Morocco

3. Higher Institute of Nursing and Health Techniques, Ministry of Health and Social Protection, Rabat 10000, Morocco

4. Laboratory of Biochemistry, Department of Applied Biological Chemistry, Faculty of Agriculture, University of Niigata, Niigata 950-2181, Japan

5. Center of Agrobiotechnology and Bioengineering, Research Unit Labelled CNRST (Centre AgroBiotech-URL-7 CNRST- 05), Cadi Ayyad University, Marrakech 40000, Morocco

6. Laboratory of Agro-Food, Biotechnologies and Valorization of Plant Bioresources (AGROBIOVAL), Department of Biology, Faculty of Science Semlalia, Cadi Ayyad University, Marrakesh 40000, Morocco

Abstract

Secondary metabolites derived from plants have demonstrated significant biological activity and hold both edible and medicinal significance. These compounds play a crucial role in the development of pharmaceuticals, particularly in the context of inflammatory disorders and chronic diseases associated with oxidative stress. The objective of this study was to investigate the chemical characterization, antioxidant potential, and antibacterial properties of the aqueous extract of Anacyclus pyrethrum (AEAP). To achieve this, we employed various analytical techniques including HPLC–ESI–MS/MS, Fourier transform infrared, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The antioxidant activity of the AEAP was assessed using DPPH (2,2-Diphenyl-1-picrylhydrazyl) and reducing power assays, while antibacterial activity was evaluated against both Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecium) using the broth microdilution assay. Our findings demonstrated significant antioxidant activity of the AEAP, as well as broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. HPLC analysis identified important bioactive compounds, notably pellitorine and 3,4-dihydroxybenzoic acid, known for their antioxidant and antibacterial properties. Overall, the AEAP demonstrated potent antioxidant and antibacterial activities, suggesting its potential as a valuable natural source of bioactive compounds with various therapeutic applications.

Publisher

MDPI AG

Subject

Horticulture,Plant Science

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