Comparative Evaluation of Different Extraction Techniques for Separation of Artemisinin from Sweet Wormwood (Artemisia annua L.)-Reference-Cited by-同舟云学术

Comparative Evaluation of Different Extraction Techniques for Separation of Artemisinin from Sweet Wormwood (Artemisia annua L.)

Published:2023-05-26 Issue:6 Volume:9 Page:629
ISSN:2311-7524
Container-title:Horticulturae
language:en
Short-container-title:Horticulturae

Author:

Banožić Marija¹^ORCID,Wronska Aleksandra Weronika²,Jakovljević Kovač Martina³,Aladić Krunoslav³^ORCID,Jerković Igor⁴^ORCID,Jokić Stela³^ORCID

Affiliation:

1. Faculty of Agriculture and Food Technology, University of Mostar, Biskupa Čule bb, 88000 Mostar, Bosnia and Herzegovina

2. Faculty of Biotechnology and Food Sciences, Lodz University of Technology, ul. Wólczańska 171/173, 90-924 Łódź, Poland

3. Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 18, 31000 Osijek, Croatia

4. Faculty of Chemistry and Technology, University of Split, R. Boškovića 35, 21000 Split, Croatia

Abstract

Sweet wormwood (Artemisia annua L.) valorization is gaining importance due to the presence of the health-promoting bioactive compound, artemisinin. Considering the wide possible application of artemisinin drug formulations, new, greener technologies in their production are welcome. In this study, artemisinin was extracted from A. annua leaves using green extraction technologies (ultrasound-assisted extraction, supercritical CO2 extraction, deep eutectic solvent extraction and subcritical water extraction) in combination with green solvents. Artemisinin was present up to 3.21 µg/mgdw. Among the different green extraction techniques, HPLC data revealed supercritical CO2 (SCO2) extracts to exhibit the highest yield of artemisinin due to the solvent non-polar properties. Additionally, the volatile compounds profile of SCO2 extract was determined, with camphor (12.23%), arteannuin b (15.29%) and artemisia ketone (10.97%) as the most abundant compounds. Obtained results encourage the use of green extraction techniques for the separation of artemisinin and are expected to find potential in pharmaceutical, cosmetic and food applications.

Publisher

MDPI AG

Subject

Horticulture,Plant Science

Link

https://www.mdpi.com/2311-7524/9/6/629/pdf

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