Impact of Single Hemodialysis Treatment on immune Cell Subpopulations

Author:

Donadei Chiara1ORCID,Angeletti Andrea2ORCID,Pizzuti Valeria3ORCID,Zappulo Fulvia1,Conte Diletta3,Cappuccilli Maria3ORCID,Chiocchini Anna Laura1ORCID,Scrivo Anna1,Apuzzo Delia1,Mariggiò Maria Addolorata4,Gasperoni Lorenzo15,Donati Gabriele67ORCID,La Manna Gaetano13

Affiliation:

1. Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy

2. Division of Nephrology, Dialysis and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa Largo Gaslini, 16148 Genoa, Italy

3. Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy

4. Department of Precision and Regenerative Medicine and Area Jonica, School of Medicine, University of Bari, 70121 Bari, Italy

5. Nephrology and Dialysis Unit, Infermi Hospital, AUSL Romagna, 47923 Rimini, Italy

6. Nephrology, Dialysis and Renal Transplant Unit, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy

7. Surgical, Medical, Dental and Morphological Sciences Department (CHIMOMO), University of Modena and Reggio Emilia, 41124 Modena, Italy

Abstract

Hemodialysis (HD) is known to trigger a chronic inflammatory status, affecting the innate and acquired immune response. This study was aimed at a comparative analysis of immune cell subsets, proliferation, and apoptosis in subjects receiving chronic HD treatment with respect to a healthy control. Regardless of the dialysis filter used, we observed a reshaping of the acquired immune component both with respect to healthy patients and between the various sessions of dialysis treatment, with an impairment of CD3 cells, along with an increase in CD4 and CD8 cell populations producing pro-inflammatory factors such as IL-17 and IFN-gamma. The population of B cells, monocytes and NK cells were not impaired by the dialysis procedure. These results confirmed the high impact of the HD treatment on the patient’s immune system, underlying the imbalance of T cell counterparts.

Publisher

MDPI AG

Subject

General Medicine

Reference29 articles.

1. Epidemiology of End-Stage Kidney Disease;Gupta;Semin. Vasc. Surg.,2021

2. The cardiovascular burden of end-stage renal disease patients;Cianciolo;Minerva Urol. Nefrol.,2010

3. T-Lymphocyte Subsets Alteration, Infection and Renal Outcome in Advanced Chronic Kidney Disease;Xiong;Front. Med.,2021

4. Characteristics and causes of immune dysfunction related to uremia and dialysis;Hauser;Perit. Dial Int.,2008

5. Cytokine Dysregulation in Chronic Kidney Disease: How Can We Treat It?;Carrero;Blood Purif.,2008

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