Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)-Reference-Cited by-同舟云学术

Enteral Nutrition during Radiotherapy for Oropharyngeal Cancers: Prevalence and Prognostic Factors Based on HPV Status (A GETTEC Study)

Published:2023-04-28 Issue:9 Volume:12 Page:3169
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Culié Dorian¹²,Schiappa Renaud²^ORCID,Pace-Loscos Tanguy²,Guelfucci Bruno³,Vergez Sebastien⁴^ORCID,Garrel Renaud⁵,Fakhry Nicolas⁶,Dassonville Olivier¹,Poissonnet Gilles¹,Lallemant Benjamin⁷,Sudaka Anne⁸,Saada-Bouzid Esma⁹,Benezery Karen¹⁰,Temam Stephane¹¹,Gorphe Phillipe¹¹,Chamorey Emmanuel²^ORCID,Bozec Alexandre¹^ORCID

Affiliation:

1. Antoine Lacassagne Centre, University Institute of the Face and Neck, Côte d’Azur University, 06000 Nice, France

2. Antoine Lacassagne Centre, Department of Epidemiology, Biostatistics and Health Data, Côte d’Azur University, 06000 Nice, France

3. Department of Otorhinolaryngology and Head and Neck Surgery, Sainte Musse Hospital, 83100 Toulon, France

4. Department of Otorhinolaryngology and Head and Neck Surgery, Cancer University Institute of Toulouse, 31100 Toulouse, France

5. Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Montpellier, 34295 Montpellier, France

6. Department of Otorhinolaryngology and Head and Neck Surgery, Public Assistance—Hospitals of Marseille, 13005 Marseille, France

7. Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Nîmes, 30900 Nîmes, France

8. Antoine Lacassagne Centre, Department of Pathology, Côte d’Azur University, 06000 Nice, France

9. Antoine Lacassagne Centre, Department of Medical Oncology, Côte d’Azur University, 06000 Nice, France

10. Antoine Lacassagne Centre, Department of Radiotherapy, Côte d’Azur University, 06000 Nice, France

11. Department of Otorhinolaryngology and Head and Neck Surgery, Gustave Roussy Institute, 94805 Villejuif, France

Abstract

Nutritional support during radiotherapy is crucial to tolerating and completing oropharyngeal squamous cell carcinoma (OPSCC) treatment. The impact of HPV status on nutritional support is debated. The objective was to evaluate the rate of Reactive Feeding Tube (RFT) use and determine its prognostic factors during definitive radiotherapy for OPSCC. All OPSCC patients treated from 2009 to 2014 were included in this multicentric retrospective study. The impact of tumor p16 status on the risk of RFT was assessed through multivariate analyses. Among the 543 patients, 103 patients required an RFT (19.0%). The use of RFT differed between centers (5% to 32.4%). In multivariate analysis, only tongue base involvement and concurrent chemotherapy were significantly associated with RFT (OR = 2.18 and 3.7, respectively). Tongue base involvement and concomitant chemotherapy were prognostic factors for RFT. HPV status was not a prognostic factor for enteral nutrition during radiotherapy for OPSCC.

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2077-0383/12/9/3169/pdf

Reference54 articles.

1. Detection and evaluation of malnutrition in oncology: What tools, what type of cancer and for what purposes?;Khan;Bull. Cancer,2016

2. Early nutrition support therapy in patients with head-neck cancer;Nutr. Hosp.,2018

3. Initial Symptoms in Patients With HPV-Positive and HPV-Negative Oropharyngeal Cancer;McIlwain;JAMA Otolaryngol.–Head Neck Surg.,2014

4. Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy;Nugent;Cochrane Database Syst. Rev.,2013

5. Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy;Langius;Br. J. Cancer,2013