Scleral Thickness as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovasculopathy
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Published:2023-04-24
Issue:9
Volume:12
Page:3102
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ISSN:2077-0383
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Container-title:Journal of Clinical Medicine
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language:en
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Short-container-title:JCM
Author:
Keidel Leonie F.1, Schworm Benedikt1ORCID, Langer Julian1, Luft Nikolaus1, Herold Tina1, Hagenau Felix1ORCID, Klaas Julian E.1, Priglinger Siegfried G.1ORCID, Siedlecki Jakob1
Affiliation:
1. Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany
Abstract
In the pathophysiology of central serous chorioretinopathy (CSC), scleral changes inducing increased venous outflow resistance are hypothesized to be involved. This work aims to investigate anterior scleral thickness (AST) as a risk factor for pachychoroid disorders. A randomized prospective case-control study was performed at the Ludwig Maximilians University, Department of Ophthalmology. In patients with CSC or pachychoroid neovasculopathy (PNV) and in an age- and refraction-matched control group, swept source optical coherence tomography (SS-OCT) was used to measure anterior scleral thickness (AST). Subfoveal choroidal thickness (SFCT) was assessed using enhanced depth imaging OCT (EDI-OCT). In total, 46 eyes of 46 patients were included in this study, with 23 eyes in the CSC/PNV and 23 eyes in the control group. A significantly higher AST was found in the CSC/PNV compared with the control group (403.5 ± 68.6 (278 to 619) vs. 362.5 ± 62.6 (218 to 498) µm; p = 0.028). Moreover, the CSC/PNV group showed a higher SFCT (392.8 ± 92.8 (191–523) vs. 330.95 ± 116.5 (167–609) µm, p = 0.004). Compared with the age- and refraction-matched controls, patients with CSC and PNV showed a significantly thicker anterior sclera. Scleral thickness might contribute to the venous overload hypothesized to induce pachychoroid phenotypes.
Reference37 articles.
1. The Pachychoroid Disease Spectrum—And the Need for a Uniform Classification System;Siedlecki;Ophthalmol. Retin.,2019 2. Quantitative Assessment of Asymmetric Choroidal Outflow in Pachychoroid Eyes on Ultra-Widefield Indocyanine Green Angiography;Jung;Investig. Opthalmology Vis. Sci.,2020 3. Matsumoto, H., Mukai, R., Hoshino, J., Oda, M., Matsuzaki, T., Ishizaki, Y., Shibasaki, K., and Akiyama, H. (2021). Choroidal congestion mouse model: Could it serve as a pachychoroid model?. PLoS ONE, 16. 4. Kishi, S., Matsumoto, H., Sonoda, S., Hiroe, T., Sakamoto, T., and Akiyama, H. (2018). Geographic filling delay of the choriocapillaris in the region of dilated asymmetric vortex veins in central serous chorioretinopathy. PLoS ONE, 13. 5. Keidel, L., Schworm, B., Langer, J., Luft, N., Herold, T., Hagenau, F., Priglinger, S.G., and Siedlecki, J. (2022, July 21). Pachysclera as a Risk Factor for Central Serous Chorioretinopathy and Pachychoroid Neovascularisation [Abstract]. Available online: https://euretina.org/resource/abstract_2022_pachysclera-as-a-risk-factor-for-central-serous-chorioretinopathy-and-pachychoroid-neovascularisation/.
Cited by
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