Ledderhose’s Disease: An Up-to-Date Review of a Rare Non-Malignant Disorder
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Published:2023-09-28
Issue:5
Volume:13
Page:1182-1195
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ISSN:2039-7283
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Container-title:Clinics and Practice
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language:en
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Short-container-title:Clinics and Practice
Author:
Tomac Alexandru1, Ion Alexandru Petru2, Opriș Diana Roxana3, Arbănași Eliza Mihaela4ORCID, Ciucanu Claudiu Constantin5, Bandici Bogdan Corneliu5, Coșarcă Cătălin Mircea5, Covalcic Diana Carina5, Mureșan Adrian Vasile56
Affiliation:
1. Clinic of Plastic Surgery, Saint Spiridon Emergency Clinical Hospital, 700111 Iasi, Romania 2. George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania 3. Emergency Institute of Cardiovascular Diseases and Transplantation (IUBCVT), 540139 Targu Mures, Romania 4. Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania 5. Clinic of Vascular Surgery, Mures County Emergency Hospital, 540136 Targu Mures, Romania 6. Department of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania
Abstract
Plantar fibromatosis (or Ledderhose’s disease) is a rare benign condition, difficult to treat, defined by gradual-growing nodules in the central medial part of the plantar fascia, with the possibility of sclerosis and shrinkage of the entire fascia or, rarely, contractures of the toes. From a histopathological point of view, it is linked to Dupuytren’s contracture of the hand and Peyronie’s disease of the penis, being part of a large group of fibromatoses, based on a proliferation of collagen and fibroblasts. Its etiology is still not fully understood, even though it has been associated with trauma, diabetes mellitus, use of anticonvulsants, frozen shoulder, alcohol consumption, and liver disease. Typically, ultrasound confirms the diagnosis, and magnetic resonance imaging is used for more aggressive and advanced types. Several conservative treatment techniques, such as steroid injections, verapamil, imatinib, radiation therapy, extracorporeal shock wave therapy, tamoxifen, sorafenib, mitomycin C, and collagenase, have been documented. When non-operative care fails, surgical measures may be considered, even though recurrence is expected. We attempted to provide a better understanding of this disease by covering all of the important aspects: its history, clinical and radiologic findings, diagnosis, pathophysiology features, conservative and surgical treatment, recurrence rate, and prognosis.
Reference89 articles.
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