(E)-5-[Bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole-Reference-Cited by-同舟云学术

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(E)-5-[Bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole

Published:2024-02-02 Issue:1 Volume:2024 Page:M1769
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Morita Nobuyoshi¹,Kurami Saki¹,Ishii Naho¹,Tanaka Kosaku¹²,Hashimoto Yoshimitsu¹,Tamura Osamu¹

Affiliation:

1. Department of Pharmacy, Showa Pharmaceutical University, Machida 194-8543, Japan

2. Research Foundation ITSUU Laboratory, C1232 Kanagawa Science Park R & D Building, 3-2-1 Sakado Takatsu-ku, Kawasaki 213-0012, Japan

Abstract

One-pot synthesis of (E)-5-[bromo(phenyl)methylene]-4-phenyl-2-(p-tolyl)-4,5-dihydrooxazole (9) from propargylic alcohol 5 and p-toluamide (6) was achieved via gold(III)-catalyzed propargylic substitution, followed by gold(III)-catalyzed bromocyclization. The structure of 9 was confirmed by an X-ray crystallographic analysis.

Funder

JSPS KAKENHI

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-8599/2024/1/M1769/pdf

Reference18 articles.

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4. From aziridines to oxazolines and thiazolines: The heterocyclic route to thiangazole;Wipf;Synlett,1997

5. Enantioselective catalytic cyclopropanation-rearrangement approach to chiral spiroketals;Dong;Org. Lett.,2021

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