Investigation of Porous Ceramic Structures Based on Hydroxyapatite and Wollastonite with Potential Applications in the Field of Tissue Engineering

Abstract

Bioceramics are the most promising materials used for hard tissue reconstruction. In this study, wollastonite/hydroxyapatite (HAp/WS)-type composite ceramic structures were synthesized with the aim of reaching a material with improved properties for use in bone tissue regeneration. The scaffolds were synthesized using a foam replica method, starting from ceramic powders with different mass ratios. These were subsequently studied and compared to identify the ideal mass ratio in terms bioactive character, appropriate mechanical properties, but also microstructural influence. The results indicate that all of the samples showed a highly porous microstructure with interconnected pores and high mineralization after 21 days of immersion in SBF. The porous structures with 90% and 70% mass contents of hydroxyapatite presented a well-defined structure and the highest values of mechanical compressive strength. Biocompatibility evaluation showed that osteoblast-like cells are able to penetrate the inner volume of the structures, exhibiting a biocompatible behavior in terms of morphological features and viability following 7 days of incubation. All results show that the porous composite ceramics with 90% and 70% mass contents of hydroxyapatite are promising materials for bone tissue regeneration.