Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice-Reference-Cited by-同舟云学术

Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice

Published:2024-01-19 Issue:1 Volume:16 Page:152
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Murray Jackelyn¹,Martin David E.²^ORCID,Hosking Sarah¹,Orr-Burks Nichole¹^ORCID,Hogan Robert J.¹,Tripp Ralph A.¹²^ORCID

Affiliation:

1. Animal Health Research Center, Department of Infectious Diseases, College of Veterinary Medicine Athens, University of Georgia, Athens, GA 30605, USA

2. TrippBio, Inc., Jacksonville, FL 32256, USA

Abstract

Avian influenza (AI) viruses cause infection in birds and humans. Several H5N1 and H7N9 variants are highly pathogenic avian influenza (HPAI) viruses. H5N1 is a highly infectious bird virus infecting primarily poultry, but unlike other AIs, H5N1 also infects mammals and transmits to humans with a case fatality rate above 40%. Similarly, H7N9 can infect humans, with a case fatality rate of over 40%. Since 1996, there have been several HPAI outbreaks affecting humans, emphasizing the need for safe and effective antivirals. We show that probenecid potently inhibits H5N1 and H7N9 replication in prophylactically or therapeutically treated A549 cells and normal human broncho-epithelial (NHBE) cells, and H5N1 replication in VeroE6 cells and mice.

Funder

Georgia Research Alliance

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4915/16/1/152/pdf

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