Prolongated Activated Partial Thromboplastin Time (aPTT) in Pediatric Patients before Surgery—Crying Wolf: Lupus (Anticoagulant) Does Not Always Threaten Children-Reference-Cited by-同舟云学术

Prolongated Activated Partial Thromboplastin Time (aPTT) in Pediatric Patients before Surgery—Crying Wolf: Lupus (Anticoagulant) Does Not Always Threaten Children

Published:2024-03-06 Issue:5 Volume:13 Page:1510
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Martini Tiziano¹^ORCID,Santoro Rita Carlotta²^ORCID,Banov Laura³,Ierardi Antonella²^ORCID,Leotta Marzia²^ORCID,Strangio Alessandra²,Svahn Johanna³,Molinari Angelo Claudio³^ORCID

Affiliation:

1. Immuno-Haematology and Transfusion Medicine, Center for Congenital Bleeding Disorders, Cesena General Hospital, 47521 Cesena, Italy

2. Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Dulbecco, 88100 Catanzaro, Italy

3. Thrombosis and Hemostasis Unit, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy

Abstract

A prolonged preoperatory aPTT in children is often the cause of a delay of scheduled surgeries and the repetition of multiple blood tests, with the consequent wasting of resources and significant discomfort for children and parents. The aim of this review is to analyze the situations in which an isolated prolongation of aPTT is found during preoperative evaluation in children, especially when it is due to the presence of antiphospholipid antibodies, providing the readers with the keys to interpret this situation and the possibility to correctly evaluate the hemorrhagic risk of a patient.

Publisher

MDPI AG

Link

https://www.mdpi.com/2077-0383/13/5/1510/pdf

Reference40 articles.

1. Santoro, R.C., Molinari, A.C., Leotta, M., and Martini, T. (2023). Isolated Prolongation of Activated Partial Thromboplastin Time: Not Just Bleeding Risk!. Medicina, 59.

2. Laboratory Diagnosis of the Lupus Anticoagulant;Smith;Curr. Rheumatol. Rep.,2012

3. Molinari, A.C., Martini, T., Banov, L., Ierardi, A., Leotta, M., Strangio, A., and Santoro, R.C. (2023). Lupus Anticoagulant Detection under the Magnifying Glass. J. Clin. Med., 12.

4. Diagnosis and Classification of the Antiphospholipid Syndrome;Cervera;J. Autoimmun.,2014

5. The Geoepidemiology of the Antiphospholipid Antibody Syndrome;Biggioggero;Autoimmun. Rev.,2010