The Effect of Polysaccharides on Preventing Proteins and Cholesterol from Being Adsorbed on the Surface of Orthokeratology Lenses

Author:

Wu Ting-Yao,Yeh Lung-Kun,Su Chen-Ying,Huang Pin-Hsuan,Lai Chi-Chun,Fang Hsu-Wei

Abstract

The adsorption of tear film compositions such as proteins and lipids on the orthokeratology lenses often lead to infection or corneal damage. In order to investigate whether polysaccharides could prevent tear compositions from being adsorbed on the lens, alginic acid and lambda-carrageenan were added into artificial tear solution. By measuring daily adsorption of cholesterol, lysozyme, and albumin, our results showed that polysaccharides could weakly prevent cholesterol adsorption. In addition, polysaccharides could also reduce albumin deposition over time. Although the effect of polysaccharides on lysozyme adsorption was distinct depending on the concentrations of polysaccharides, the overall results demonstrated that polysaccharides could decrease protein deposition over time. Our results provided an in vitro evidence that polysaccharides may be applied as coating materials on the lens or as the composition of artificial tear solutions or eyedrops, in order to prevent adsorption of tear film compositions that may lead to a reduced incidence of infection or corneal damage for orthokeratology lens wearers.

Funder

Ministry of Science and Technology (MOST), Taiwan

National Taipei University of Technology and Chang Gung Memorial Hospital Joint Research Program

Chang Gung Medical Research Project

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

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