Affiliation:
1. School of Energy and Power Engineering, Lanzhou University of Technology, Lanzhou 730050, China
2. Chongqing Key Laboratory of Micro-Nano System and Intelligent Sensing, Chongqing Technology and Business University, Chongqing 400067, China
Abstract
Enrichment of erythrocytes is a necessary step in the diagnosis of blood diseases. Due to the high deformability and viscosity of erythrocytes, they cannot be regarded as stable point-like solids, so the influence of their deformability on fluid dynamics must be considered. Therefore, by using the special effect of an I-shaped pillar (I-pillar) on erythrocytes, erythrocytes with different deformability can be made to produce different provisional distances in the chip, so as to achieve the separation of the two kinds of erythrocytes. In this study, a microfluidic chip was designed to conduct a control test between erythrocytes stored for a long time and fresh erythrocytes. At a specific flow rate, the different deformable erythrocytes in the chip move in different paths. Then, the influence of erythrocyte deformability on its movement trajectory was analyzed by two-dimensional finite element flow simulation. DLD sorting technology provides a new method for the sorting and enrichment of diseased erythrocytes.
Funder
Key Program of the National Natural Science Foundation of China
National Natural Science Foundation of China
Double First-Class Key Program of Gansu Provincial Department of Education
2022 Gansu Provincial University Industry Support Plan Project
Key R&D Program of Gansu Province of China
Key Laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education
Subject
Electrical and Electronic Engineering,Mechanical Engineering,Control and Systems Engineering
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