Platelet Transfusion—Insights from Current Practice to Future Development

Author:

Capraru Annina,Jalowiec Katarzyna AleksandraORCID,Medri Cesare,Daskalakis Michael,Zeerleder Sacha Sergio,Mansouri Taleghani Behrouz

Abstract

Since the late sixties, therapeutic or prophylactic platelet transfusion has been used to relieve hemorrhagic complications of patients with, e.g., thrombocytopenia, platelet dysfunction, and injuries, and is an essential part of the supportive care in high dose chemotherapy. Current and upcoming advances will significantly affect present standards. We focus on specific issues, including the comparison of buffy-coat (BPC) and apheresis platelet concentrates (APC); plasma additive solutions (PAS); further measures for improvement of platelet storage quality; pathogen inactivation; and cold storage of platelets. The objective of this article is to give insights from current practice to future development on platelet transfusion, focusing on these selected issues, which have a potentially major impact on forthcoming guidelines.

Publisher

MDPI AG

Subject

General Medicine

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