A Risk-Structured Model for the Transmission Dynamics of Anthrax Disease

Author:

Akande Kazeem Babatunde1ORCID,Akinyemi Samuel Tosin2,Iheonu Nneka O.3,Audu Alogla Monday4,Jimoh Folashade Mistura5,Ojoma Atede Anne3,Okeowo Victoria Iyabode6,Suleiman Abdulrahaman Lawal67,Oshinubi Kayode8ORCID

Affiliation:

1. Department of Mathematical Sciences, Baze University, Abuja 900108, FCT, Nigeria

2. Department of Mathematics, Sikiru Adetona College of Education, Science and Technology, Ijebu-Ode 2128, Ogun State, Nigeria

3. Department of Mathematics, Federal University of Technology, Owerri 1526, Imo State, Nigeria

4. Department of Mathematics, Nasarawa State University, Keffi 1022, Nasarawa State, Nigeria

5. Department of Physical Sciences, Al-Hikmah University, Ilorin 240001, Kwara State, Nigeria

6. Department of Mathematical Sciences, Stellenbosch University, Stellenbosch 7602, South Africa

7. Department of Mathematics, Federal University Dutse, Dutse 720222, Jigawa State, Nigeria

8. School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ 86011, USA

Abstract

Anthrax, a zoonotic disease with serious public health consequences, has been the subject of rigorous mathematical and statistical modeling to better understand its dynamics and to devise effective control techniques. In this study, we propose a novel mathematical risk-structured model for anthrax disease spread that includes both qualitative and quantitative evaluations. Our research focuses on the complex interplay between host–anthrax interactions and zoonotic transmission. Our mathematical approach incorporates bifurcation analysis and stability considerations. We investigate the dynamic behavior of the proposed model under various settings, shedding light on the important parameters that determine anthrax transmission and persistence. The normalized forward sensitivity analysis method is used to determine the parameters that are relevant to reducing Rc and, by extension, disease spread. Through scenario simulation of our model, we identify intervention techniques, such as enlightenment of the populace, that will effectively minimize disease transmission. Our findings provide insights into anthrax epidemiology and emphasize the importance of effective disease management. Bifurcation investigations reveal the existence and stability of numerous equilibria, allowing for a better understanding of the behavior of the system under various scenarios. This study adds to the field of anthrax modeling by providing a foundation for informed decision-making regarding public health measures. The use of a mathematical modeling approach improves our ability to anticipate and control anthrax epidemics, ultimately helping to protect both human and animal populations.

Publisher

MDPI AG

Reference29 articles.

1. Center for Disease Control (CDC) (2023, November 08). National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Available online: https://www.cdc.gov/anthrax/basics/index.html.

2. A review of cutaneous anthrax and its outcome;Doganay;J. Infect. Public Health,2010

3. Review of anthrax: A disease of farm animals;Alam;J. Adv. Vet. Anim. Res.,2022

4. World Health Organization, and International Office of Epizootics (2008). Anthrax in Humans and Animals, World Health Organization.

5. The ecology of anthrax spores: Tough but not invincible;Dragon;Can. Vet. J.,1995

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