1. Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
2. Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA 17033, USA
3. Department of Comparative Medicine, Penn State College of Medicine, Hershey, PA 17033, USA
4. Division of Biostatistics and Bioinformatics, Penn State College of Medicine, Hershey, PA 17033, USA