African Swine Fever Virus Interaction with Host Innate Immune Factors-Reference-Cited by-同舟云学术

African Swine Fever Virus Interaction with Host Innate Immune Factors

Published:2023-05-23 Issue:6 Volume:15 Page:1220
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Afe Ayoola Ebenezer¹²^ORCID,Shen Zhao-Ji²,Guo Xiaorong³,Zhou Rong²,Li Kui¹

Affiliation:

1. Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China

2. State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

3. Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan 528231, China

Abstract

African swine fever virus (ASFV) adversely affects pig farming owing to its 100% mortality rate. The condition is marked by elevated body temperature, bleeding, and ataxia in domestic pigs, whereas warthogs and ticks remain asymptomatic despite being natural reservoirs for the virus. Breeding ASFV-resistant pigs is a promising solution for eradicating this disease. ASFV employs several mechanisms to deplete the host antiviral response. This review explores the interaction of ASFV proteins with innate host immunity and the various types of machinery encompassed by viral proteins that inhibit and induce different signaling pathways, such as cGAS-STING, NF-κB, Tumor growth factor-beta (TGF-β), ubiquitination, viral inhibition of apoptosis, and resistance to ASFV infection. Prospects for developing a domestic pig that is resistant to ASFV are also discussed.

Funder

Key Technologies R&D Program of Guangdong Province

National Natural Science Foundation of China

Central Public-interest Scientific Institution Basal Research Fund

Yunnan Key Research and Development Project

Chinese Government Scholarship

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/15/6/1220/pdf

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