Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients-Reference-Cited by-同舟云学术

Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients

Published:2024-07-29 Issue:15 Volume:25 Page:8259
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

De Lorenzo Rebecca¹²,Loré Nicola I.¹²^ORCID,Finardi Annamaria³,Mandelli Alessandra³^ORCID,Calesella Federico⁴⁵,Palladini Mariagrazia⁴⁵^ORCID,Cirillo Daniela M.⁶^ORCID,Tresoldi Cristina⁷,Ciceri Fabio²⁷,Rovere-Querini Patrizia¹²,Manfredi Angelo A.¹²^ORCID,Mazza Mario G.⁵,Benedetti Francesco²⁴⁵,Furlan Roberto³^ORCID

Affiliation:

1. Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, 20132 Milan, Italy

2. Faculty of Medicine, Università Vita-Salute San Raffaele, 20132 Milan, Italy

3. Institute of Experimental Neurology, Division of Neuroscience, IRCCS Ospedale San Raffaele, 20132 Milan, Italy

4. Faculty of Psychology, Università Vita-Salute San Raffaele, 20132 Milan, Italy

5. Psychiatry and Clinical Psychobiology, Division of Neuroscience, IRCCS Ospedale San Raffaele, 20132 Milan, Italy

6. Emerging Bacterial Pathogens Unit, IRCCS Ospedale San Raffaele, 20132 Milan, Italy

7. Hematology and Bone Marrow Transplant, IRCCS Ospedale San Raffaele, 20132 Milan, Italy

Abstract

Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.

Funder

Italian Ministry of Health

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/15/8259/pdf

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