Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option?

Author:

Bieri Shania1,Möller Burkhard2ORCID,Amsler Jennifer23ORCID

Affiliation:

1. Faculty of Medicine, University of Bern, 3012 Bern, Switzerland

2. Department of Rheumatology and Immunology, Bern University Hospital, University of Bern, 3010 Bern, Switzerland

3. Department for BioMedical Research DBMR, University of Bern, 3008 Bern, Switzerland

Abstract

Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation of lipid peroxides. In this review, we summarize research on the impact of ferroptosis on disease models and isolated cells in various types of arthritis. While most studies have focused on rheumatoid arthritis (RA) and osteoarthritis (OA), there is limited research on spondylarthritis and crystal arthropathies. The effects of inducing or inhibiting ferroptosis on the disease strongly depend on the studied cell type. In the search for new therapeutic targets, inhibiting ferroptosis in chondrocytes might have promising effects for any type of arthritis. On the other hand, ferroptosis induction may also lead to a desired decrease of synovial fibroblasts in RA. Thus, ferroptosis research must consider the cell-type-specific effects on arthritis. Further investigation is needed to clarify these complexities.

Publisher

MDPI AG

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