The “Forgotten” Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors-Reference-Cited by-同舟云学术

The “Forgotten” Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors

Published:2024-08-01 Issue:15 Volume:25 Page:8382
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Koufopoulos Nektarios I.¹^ORCID,Boutas Ioannis²^ORCID,Pouliakis Abraham¹^ORCID,Samaras Menelaos G.¹,Kotanidis Christakis¹,Kontogeorgi Adamantia³,Dimas Dionysios T.⁴,Ieronimaki Argyro-Ioanna¹,Leventakou Danai¹^ORCID,Spathis Aris¹^ORCID,Zanelli Magda⁵^ORCID,Palicelli Andrea⁵^ORCID,Zizzo Maurizio⁶⁷^ORCID,Goutas Dimitrios⁸^ORCID,Pateras Ioannis S.¹,Panayiotides Ioannis G.¹^ORCID

Affiliation:

1. Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece

2. Breast Unit, Rea Maternity Hospital, Palaio Faliro, 17564 Athens, Greece

3. Third Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece

4. Breast Unit, Athens Medical Center, Psychiko Clinic, 11525 Athens, Greece

5. Pathology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy

6. Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy

7. Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, 41121 Modena, Italy

8. First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece

Abstract

Breast carcinoma is the most common cancer in women. Nineteen different subtypes of breast carcinomas are recognized in the current WHO classification of breast tumors. Except for these subtypes, there are a number of carcinomas with special morphologic and immunohistochemical features that are not included in the 5th WHO classification, while others are considered special morphologic patterns of invasive breast carcinoma of no special type. In this manuscript, we systematically review the literature on four different subtypes of invasive breast carcinoma, namely lymphoepithelioma-like breast carcinoma, breast carcinoma with osteoclast-like giant cells, signet-ring breast carcinoma, and metaplastic breast carcinoma with melanocytic differentiation. We describe their clinicopathological characteristics, focusing on the differential diagnosis, treatment, and prognosis.

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-0067/25/15/8382/pdf

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