Genetic Factors Implicated in the Investigation of Possible Connections between Alzheimer’s Disease and Primary Open Angle Glaucoma

Author:

Kuang Grace1,Salowe Rebecca1,O’Brien Joan1

Affiliation:

1. Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Abstract

Both Alzheimer’s disease (AD) and primary open angle glaucoma (POAG) are diseases of primary global neurodegeneration with complex pathophysiologies. Throughout the published literature, researchers have highlighted similarities associated with various aspects of both diseases. In light of the increasing number of findings reporting resemblance between the two neurodegenerative processes, scientists have grown interested in possible underlying connections between AD and POAG. In the search for explanations to fundamental mechanisms, a multitude of genes have been studied in each condition, with overlap in the genes of interest between AD and POAG. Greater understanding of genetic factors can drive the research process of identifying relationships and elucidating common pathways of disease. These connections can then be utilized to advance research as well as to generate new clinical applications. Notably, AD and glaucoma are currently diseases with irreversible consequences that often lack effective therapies. An established genetic connection between AD and POAG would serve as the basis for development of gene or pathway targeted strategies relevant to both diseases. Such a clinical application could be of immense benefit to researchers, clinicians, and patients alike. This paper aims to summarize the genetic associations between AD and POAG, describe common underlying mechanisms, discuss potential areas of application, and organize the findings in a review.

Funder

National Institutes of Health

Vision Research Core Grant

F.M. Kirby Foundation

Research to Prevent Blindness

The UPenn Hospital Board of Women Visitors

The Paul and Evanina Bell Mackall Foundation Trust

Regeneron Genetics Center

phthalmology Department at the Perelman School of Medicine

VA Hospital in Philadelphia, PA

Publisher

MDPI AG

Subject

Genetics (clinical),Genetics

Reference89 articles.

1. Epidemiology of Alzheimer Disease;Mayeux;Cold Spring Harb. Perspect. Med.,2012

2. Epidemiology of Glaucoma: The Past, Present, and Predictions for the Future;Allison;Cureus,2020

3. Definition of glaucoma: Clinical and experimental concepts;Casson;Clin. Exp. Ophthalmol.,2012

4. Biological subtypes of Alzheimer disease: A systematic review and meta-analysis;Ferreira;Neurology,2020

5. Black and White individuals differ in dementia prevalence, risk factors, and symptomatic presentation;Lennon;Alzheimer’s Dement.,2021

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3