Estimates of Genomic Heritability and the Marker-Derived Gene for Re(Production) Traits in Xinggao Sheep
Author:
Liu Zaixia12ORCID, Fu Shaoyin3ORCID, He Xiaolong3, Liu Xuewen4, Shi Caixia1, Dai Lingli125, Wang Biao3, Chai Yuan1, Liu Yongbin6, Zhang Wenguang12
Affiliation:
1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China 2. Inner Mongolia Engineering Research Center of Genomic Big Data for Agriculture, Hohhot 010018, China 3. Institute of Animal Husbandry, Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China 4. College of Agronomy, Animal Husbandry and Bioengineering, Xing’an Vocational and Technical College, Ulanhot 137400, China 5. Veterinary Research Institute, Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China 6. School of Life Science, Inner Mongolia University, Hohhot 010021, China
Abstract
Xinggao sheep are a breed of Chinese domestic sheep that are adapted to the extremely cold climatic features of the Hinggan League in China. The economically vital reproductive trait of ewes (litter size, LS) and productive traits of lambs (birth weight, BWT; weaning weight, WWT; and average daily gain, ADG) are expressed in females and later in life after most of the selection decisions have been made. This study estimated the genetic parameters for four traits to explore the genetic mechanisms underlying the variation, and we performed genome-wide association study (GWAS) tests on a small sample size to identify novel marker trait associations (MTAs) associated with prolificacy and growth. We detected two suggestive significant single-nucleotide polymorphisms (SNPs) associated with LS and eight significant SNPs for BWT, WWT, and ADG. These candidate loci and genes also provide valuable information for further fine-mapping of QTLs and improvement of reproductive and productive traits in sheep.
Funder
Science and Technology Major Project of Inner Mongolia The National Key Research and Development Program of China Inner Mongolia Science and Technology Program the Modern Agricultural Industry Technology System of China
Subject
Genetics (clinical),Genetics
Reference66 articles.
1. Kijas, J.W., Lenstra, J.A., Hayes, B., Boitard, S., Porto Neto, L.R., San Cristobal, M., Servin, B., McCulloch, R., Whan, V., and Gietzen, K. (2012). Genome-Wide Analysis of the World’s Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection. PLoS Biol., 10. 2. Tang, J. (2019). Study on Screening Polytocous Candidate Genes in Sheep Based Transcriptome Sequencing and Proteomics. [Ph.D. Thesis, Chinese Academy of Agricultural Sciences]. 3. (2016). National Sheep Genetic Improvement Program (2021–2035). Anim. Agric., 6–8. 4. Wei, C., Wang, H., Liu, G., Wu, M., Cao, J., Liu, Z., Liu, R., Zhao, F., Zhang, L., and Lu, J. (2015). Genome-Wide Analysis Reveals Population Structure and Selection in Chinese Indigenous Sheep Breeds. BMC Genom., 16. 5. Analysis on Lambing Performance and Feeding Benefit of Xing′an Multi-Lamb Sheep;He;Anim. Husb. Feed Sci.,2021
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|