Systemic Retinoids for Generalized Verrucosis Due to Congenital Immunodeficiency: Case Reports and Review of the Literature

Author:

Kosumi Hideyuki1ORCID,Natsuga Ken2ORCID,Yanagi Teruki2ORCID,Ujiie Hideyuki2

Affiliation:

1. Department of Dermatology, Hokkaido University Hospital, Sapporo 060-8638, Japan

2. Department of Dermatology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo 060-8638, Japan

Abstract

Generalized verrucosis (GV) is a group of immunodeficiency disorders accompanied by widespread human papillomavirus infection. We revisit two cases of GV due to congenital interleukin-7 deficiency successfully treated with systemic retinoids. We also present a review of the literature on the use of systemic retinoids to treat GV. Our review suggests that systemic retinoids are a safe and effective option for managing recalcitrant wart lesions in cases of GV.

Publisher

MDPI AG

Subject

Genetics (clinical),Genetics

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