Abstract
The diarylurea is a scaffold of great importance in medicinal chemistry as it is present in numerous heterocyclic compounds with antithrombotic, antimalarial, antibacterial, and anti-inflammatory properties. Some diarylureas, serine-threonine kinase or tyrosine kinase inhibitors, were recently reported in literature. The first to come into the market as an anticancer agent was sorafenib, followed by some others. In this review, we survey progress over the past 10 years in the development of new diarylureas as anticancer agents.
Subject
Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science
Reference123 articles.
1. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry
2. The history of barbiturates a century after their clinical introduction;López-Muñoz;Neuropsychiatr. Dis. Treat.,2005
3. Ureas: Applications in Drug Design
4. Short Notes on Diaryl Ureas Derivatives;Asif;J. Adv. Res. BioChem. Pharmacol.,2018
5. Diaryl Urea: A Privileged Structure in Anticancer Agents
Cited by
38 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献