Author:
Xie Ruoxi,Zeng Xinbing,Yan Huan,Huang Xiaoping,Deng Changqing
Abstract
Cerebral ischemia refers to the symptom of insufficient blood supply to the brain. Cells of many different origins participate in the process of repairing damage after cerebral ischemia occurs, in which exosomes secreted by the cells play important roles. For their characteristics, such as small molecular weight, low immunogenicity, and the easy penetration of the blood–brain barrier (BBB), exosomes can mediate cell-to-cell communication under pathophysiological conditions. In cerebral ischemia, exosomes can reduce neuronal damage and improve the brain microenvironment by regulating inflammation, mediating pyroptosis, promoting axonal growth, and stimulating vascular remodeling. Therefore, exosomes have an excellent application prospect for the treatment of cerebral ischemia. This article reviews the roles and mechanisms of exosomes from different sources in cerebral ischemia and provides new ideas for the prevention and treatment of cerebral ischemia.
Reference108 articles.
1. Shin, T.H., Lee, D.Y., Basith, S., Manavalan, B., Paik, M.J., Rybinnik, I., Mouradian, M.M., Ahn, J.H., and Lee, G. (2020). Metabolome Changes in Cerebral Ischemia. Cells, 9.
2. The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia;Curr. Pharm. Des.,2016
3. Pathogenic mechanisms following ischemic stroke;Neurol. Sci.,2017
4. Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research;Prog. Neurobiol.,2018
5. Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake;Cell Mol. Neurobiol.,2016
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