Author:
Zhang Yuhan,Sun Lingbo,Lei Changda,Li Wenyan,Han Jiaqi,Zhang Jing,Zhang Yuecheng
Abstract
Glycosylation is a common post-translational modification process of proteins. Mucin-type O-glycosylation is an O-glycosylation that starts from protein serine/threonine residues. Normally, it is involved in the normal development and differentiation of cells and tissues, abnormal glycosylation can lead to a variety of diseases, especially cancer. This paper reviews the normal biosynthesis of mucin-type O-glycans and their role in the maintenance of body health, followed by the mechanisms of abnormal mucin-type O-glycosylation in the development of diseases, especially tumors, including the effects of Tn, STn, T antigen, and different glycosyltransferases, with special emphasis on their role in the development of gastric cancer. Finally, tumor immunotherapy targeting mucin-type O-glycans was discussed.
Funder
National Natural Science Foundation of China
Health Research Project of Shaanxi Province
Scientific Research Projects of Education Department of Shaanxi Provincial Government
Ph.D. start-up fund of Yan’an University
Shaanxi Province Natural Science Foundation
Shaanxi Province Key Science and Technology innovation team
Innovation Team of Yan’an City-Innovation Team for Chronic Disease Prevention and Control
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