Abstract
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-κB) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.
Funder
Operational Programme Research, Development and Education
Centre for Tumour Ecology—Research of the Cancer Microenvironment Supporting Cancer Growth and Spread
National Institute for Cancer Research
European Union—Next Generation EU
Ministry of Education, Youth and Sports
Ministry of Health of the Czech Republic
Cited by
32 articles.
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