Abstract
The heart reacts to a large number of pathological stimuli through cardiac hypertrophy, which finally can lead to heart failure. However, the molecular mechanisms of cardiac hypertrophy remain elusive. Actin participates in the formation of highly differentiated myofibrils under the regulation of actin-binding proteins (ABPs), which provides a structural basis for the contractile function and morphological change in cardiomyocytes. Previous studies have shown that the functional abnormality of ABPs can contribute to cardiac hypertrophy. Here, we review the function of various actin-binding proteins associated with the development of cardiac hypertrophy, which provides more references for the prevention and treatment of cardiomyopathy.
Funder
National Natural Science Foundation of China
Xianning Science and Technology Plan Project
Hubei University of Science and Technology School-level Fund
Scientific Research and Innovation Team of Hubei University of Science and Technology
Reference114 articles.
1. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines;Heidenreich;Circulation,2022
2. Mechanisms of physiological and pathological cardiac hypertrophy;Nakamura;Nat. Rev. Cardiol.,2018
3. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation;Kehat;Circulation,2010
4. Cardiac hypertrophy: The good, the bad, and the ugly;Frey;Annu. Rev. Physiol.,2003
5. The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy;Liu;Circ. Res.,2022
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