Merkel Cells Are Multimodal Sensory Cells: A Review of Study Methods

Author:

Bataille AdelineORCID,Le Gall Christelle,Misery LaurentORCID,Talagas MatthieuORCID

Abstract

Merkel cells (MCs) are rare multimodal epidermal sensory cells. Due to their interactions with slowly adapting type 1 (SA1) Aβ low-threshold mechanoreceptor (Aβ-LTMRs) afferents neurons to form Merkel complexes, they are considered to be part of the main tactile terminal organ involved in the light touch sensation. This function has been explored over time by ex vivo, in vivo, in vitro, and in silico approaches. Ex vivo studies have made it possible to characterize the topography, morphology, and cellular environment of these cells. The interactions of MCs with surrounding cells continue to be studied by ex vivo but also in vitro approaches. Indeed, in vitro models have improved the understanding of communication of MCs with other cells present in the skin at the cellular and molecular levels. As for in vivo methods, the sensory role of MC complexes can be demonstrated by observing physiological or pathological behavior after genetic modification in mouse models. In silico models are emerging and aim to elucidate the sensory coding mechanisms of these complexes. The different methods to study MC complexes presented in this review may allow the investigation of their involvement in other physiological and pathophysiological mechanisms, despite the difficulties in exploring these cells, in particular due to their rarity.

Publisher

MDPI AG

Subject

General Medicine

Reference148 articles.

1. The Anatomy, Function, and Development of Mammalian Aβ Low-Threshold Mechanoreceptors;Fleming;Front. Biol.,2013

2. Intraepidermal Nerve Fibres Are Not the Exclusive Tranducers of Nociception;Talagas;J. Neurosci. Methods,2018

3. The Epidermis: A Sensory Tissue;Boulais;Eur. J. Dermatol. EJD,2008

4. Tastzellen Und Tastkörperchen Bei Den Hausthieren Und Beim Menschen;Merkel;Arch. Mikrosk. Anat.,1875

5. Merkel Cells;Boulais;J. Am. Acad. Dermatol.,2007

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3