Abstract
Intervertebral disc degeneration (IDD), a progressive and multifactorial pathological process, is predominantly associated with low back pain and permanent disability. Pyroptosis is a type of lytic programmed cell death triggered by the activation of inflammasomes and caspases. Unlike apoptosis, pyroptosis is characterized by the rupture of the plasma membrane and the release of inflammatory mediators, accelerating the destruction of the extracellular matrix (ECM). Recent studies have shown that pyrin domain-containing 3 (NLRP3) inflammasome-mediated pyroptosis in nucleus pulposus (NP) cells is activated in the progression of IDD. Furthermore, targeting pyroptosis in IDD demonstrates the excellent capacity of ECM remodeling and its anti-inflammatory properties, suggesting that pyroptosis is involved in the IDD process. In this review, we briefly summarize the molecular mechanism of pyroptosis and the pathogenesis of IDD. We also focus on the role of pyroptosis in the pathological progress of IDD and its targeted therapeutic application.
Funder
Construction Plan of the Gansu Province Clinical Research Center for Endocrine Disease
National Key R&D Program of China
Project of the Gansu Natural Science Foundation
National innovation and entrepreneurship training program for College Students
Guizhou Provincial innovation and entrepreneurship training program for College Students
Lanzhou University 2022 College Students Innovation and Entrepreneurship
Subject
Molecular Biology,Biochemistry
Cited by
4 articles.
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