Immunoglobulin A as a Key Immunological Molecular Signature of Post-COVID-19 Conditions-Reference-Cited by-同舟云学术

Immunoglobulin A as a Key Immunological Molecular Signature of Post-COVID-19 Conditions

Published:2023-07-13 Issue:7 Volume:15 Page:1545
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Sousa Graziele F.¹,Carpes Raphael M.¹,Silva Carina A. O.¹,Pereira Marcela E. P.¹^ORCID,Silva Amanda C. V. F.¹,Coelho Viktoria A. G. S.¹,Costa Evenilton P.¹,Mury Flávia B.¹,Gestinari Raquel S.¹,Souza-Menezes Jackson¹,Leal-da-Silva Manuela¹^ORCID,Nepomuceno-Silva José L.¹^ORCID,Tanuri Amilcar²^ORCID,Ferreira-Júnior Orlando C.²,Monteiro-de-Barros Cintia¹³

Affiliation:

1. Laboratório de Campanha para Testagem e Pesquisa do COVID-19 (LCC), Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Macaé 27965-045, RJ, Brazil

2. Laboratório de Virologia Molecular, Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, RJ, Brazil

3. Cintia Monteiro de Barros, Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Av. São José do Barreto 764, Macaé 27965-045, RJ, Brazil

Abstract

COVID-19 has infected humans worldwide, causing millions of deaths or prolonged symptoms in survivors. The transient or persistent symptoms after SARS-CoV-2 infection have been defined as post-COVID-19 conditions (PCC). We conducted a study of 151 Brazilian PCC patients to analyze symptoms and immunoglobulin profiles, taking into account sex, vaccination, hospitalization, and age. Fatigue and myalgia were the most common symptoms, and lack of vaccination, hospitalization, and neuropsychiatric and metabolic comorbidities were relevant to the development of PCC. Analysis of serological immunoglobulins showed that IgA was higher in PCC patients, especially in the adult and elderly groups. Also, non-hospitalized and hospitalized PCC patients produced high and similar levels of IgA. Our results indicated that the detection of IgA antibodies against SARS-CoV-2 during the course of the disease could be associated with the development of PCC and may be an immunological signature to predict prolonged symptoms in COVID-19 patients.

Funder

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Link

https://www.mdpi.com/1999-4915/15/7/1545/pdf

Reference47 articles.

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