Abstract
Notably, antibiofouling is an important and predominant technique adopted to improve the surfaces of biomaterials. In this study, polyethylene glycol-grafted polyethylene glycols bearing azidophenyl groups were synthesized and immobilized on polystyrene surfaces via photoirradiation. The prepared polymers were found to be highly soluble in water, and photoimmobilization with fluorescent proteins was confirmed based on micropatterning using a photomask. These polymers suppressed nonspecific interactions between proteins and cells on the substrate. Considering that photoimmobilization can be adopted for the covalent bond modification of various surfaces, the developed water-soluble and highly antibiofouling polymers appear to be useful in biomaterial preparation.
Subject
Polymers and Plastics,General Chemistry
Reference45 articles.
1. Antifouling Strategies for Selective in Vitro and in Vivo Sensing;Jiang;Chem. Rev.,2020
2. Zhang, P., Ratner, B.D., Hoffman, A.S., and Jiang, S. (2020). Biomaterials Science, Elsevier.
3. Ultrasmall Implantable Composite Microelectrodes with Bioactive Surfaces for Chronic Neural Interfaces;Kozai;Nat. Mater.,2012
4. Cellular-Scale Probes Enable Stable Chronic Subsecond Monitoring of Dopamine Neurochemicals in a Rodent Model;Schwerdt;Commun. Biol.,2018
5. Phosphorescent Nanosensors for in Vivo Tracking of Histamine Levels;Cash;Anal. Chem.,2013