Coating Materials to Increase the Stability of Liposomes

Author:

Pasarin Diana1ORCID,Ghizdareanu Andra-Ionela12ORCID,Enascuta Cristina Emanuela1ORCID,Matei Catalin Bogdan1,Bilbie Catalin3,Paraschiv-Palada Luciana3,Veres Petronela-Andreea3

Affiliation:

1. Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie, ICECHIM, 202 Splaiul Independentei, 060021 Bucuresti, Romania

2. Facultatea de Stiinta si Ingineria Materialelor, Universitatea Politehnica din Bucuresti, 313 Splaiul Independentei, 060042 Bucharest, Romania

3. Expergo Business Network SRL, 6 Radu Calomfirescu, 030216 Bucuresti, Romania

Abstract

Liposomes carry various compounds with applications in pharmaceutical, food, and cosmetic fields, and the administration route is especially parenteral, oral, or transdermal. Liposomes are used to preserve and release the internal components, thus maintaining the properties of the compounds, the stability and shelf life of the encapsulated products, and their functional benefits. The main problem in obtaining liposomes at the industrial level is their low stability due to fragile phospholipid membranes. To increase the stability of liposomes, phospholipid bilayers have been modified or different coating materials have been developed and studied, both for liposomes with applications in the pharmaceutical field and liposomes in the food field. In the cosmetic field, liposomes need no additional coating because the liposomal formulation is intended to have a fast penetration into the skin. The aim of this review is to provide current knowledge regarding physical and chemical factors that influence stability, coating materials for liposomes with applications in the pharmaceutical and food fields to increase the stability of liposomes containing various sensitive compounds, and absorption of the liposomes and commercial liposomal products obtained through various technologies available on the market.

Funder

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii

Publisher

MDPI AG

Subject

Polymers and Plastics,General Chemistry

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