Role of Heat Shock Proteins in Glaucoma

Author:

Tsai Teresa,Grotegut Pia,Reinehr Sabrina,Joachim Stephanie C.ORCID

Abstract

Glaucoma, one of the most common causes of blindness worldwide, is a multifactorial neurodegenerative disease characterized by damage of retinal ganglion cells and optic nerve degeneration. However, the exact mechanism leading to glaucoma is still not understood. Evidences suggest an immunological involvement in the pathogenesis. Among other immune responses, altered autoantibody patterns were found in glaucoma patients. Especially elevated antibody levels against heat shock proteins (HSPs), like HSP27 or HSP60, were identified. In an animal model, an immunization with these HSPs induced a pressure-independent retinal ganglion cell degeneration and axon loss, hence mimicking glaucoma-like damage. In addition, development of autoreactive antibodies, as well as a glia and T-cell activation, were described in these animals. Recently, we noted that intravitreal HSP27 injection likewise led to a degeneration of retinal ganglion cells and their axons. Therefore, HSP27 might have a direct damaging effect on retinal cells, and might play a key role in glaucoma.

Funder

Deutsche Forschungsgemeinschaft

Ernst und Berta Grimmke Stiftung

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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1. The gut-retina axis: Uncovering the role of autoimmunity in glaucoma development;Heliyon;2024-08

2. Ferroptosis: a novel mechanism of cell death in ophthalmic conditions;Frontiers in Immunology;2024-06-27

3. Role of T cell-induced autoimmune response in the pathogenesis of glaucoma;International Ophthalmology;2024-06-21

4. The Role of Immune Regulation in Glaucoma;Advances in Clinical Medicine;2024

5. Microbiome and T Cells in Glaucoma;Reference Module in Neuroscience and Biobehavioral Psychology;2024

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