Biosynthesis of Quercetin-Loaded Melanin Nanoparticles for Improved Antioxidant Activity, Photothermal Antimicrobial, and NIR/pH Dual-Responsive Drug Release

Author:

Zhang Di1,Chen Xianrui1,Bu Nitong1,Huang Liying1,Lin Huanglong1,Zhou Lizhen1,Mu Ruojun1ORCID,Wang Lin2,Pang Jie1

Affiliation:

1. College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China

2. Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China

Abstract

Quercetin (QCT) is a promising dose-dependent nutraceutical that usually suffers from poor water solubility and low bioavailability issues. In this work, a novel QCT-loaded nanoscale delivery system was constructed based on the oxidative self-polymerization of melanin (Q@MNPs). The FT-IR, XRD, and Zeta potential analyses confirmed that QCT was successfully absorbed on the melanin nanoparticles (MNPs) via Π−Π and hydrogen bonding interactions. The encapsulation efficiency and particle size of Q@MNPs were 43.78% and 26.68 nm, respectively. Q@MNPs improved the thermal stability of QCT and the antioxidant properties in comparison to MNPs. Meanwhile, Q@MNPs presented fantastic photothermal conversion capacity and stability triggered by the NIR laser, which significantly enhanced the antibacterial capability with a sterilization rate of more than 98% against E. coli and S. aureus. More importantly, Q@MNPs exhibited NIR/pH dual-responsive drug release behavior and good biocompatibility (at concentrations of < 100 μg/mL). Thus, Q@MNPs show promising prospects for flavonoid delivery.

Funder

Key project of Natural Science Foundation of Fujian Province

Natural Science Foundation from Fujian Provincial Department of Science and Technology

Scientific Research Foundation for Distinguished Young Scientists from Fujian Agriculture and Forestry University

China Postdoctoral Science Foundation

Publisher

MDPI AG

Subject

Plant Science,Health Professions (miscellaneous),Health (social science),Microbiology,Food Science

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