NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors

Author:

Pudakalakatti Shivanand,Audia Alessandra,Mukhopadhyay AnirudhORCID,Enriquez José S.,Bourgeois Dontrey,Tayob Nabihah,Zacharias Niki M.,Millward Steven W.,Carson Daniel,Farach-Carson Mary C.ORCID,Lang Frederick F.,Heimberger Amy B.,Bhat Krishna P.,Bhattacharya Pratip K.ORCID

Abstract

“Tumor-educated platelets” have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.

Funder

NCI

Cancer Prevention and Research Institute of Texas

U.S. Department of Defense

Publisher

MDPI AG

Subject

General Earth and Planetary Sciences,Water Science and Technology,Geography, Planning and Development

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