Gelatin Soft Actuators: Benefits and Opportunities

Abstract

Soft robots are being developed as implantable devices and surgical tools with increasing frequency. As this happens, new attention needs to be directed at the materials used to engineer these devices that interface with biological tissues. Biocompatibility will increase if traditional materials are replaced with biopolymers or proteins. Gelatin-based actuators are biocompatible, biodegradable, versatile, and tunable, making them ideal for biomedical and biomechanical applications. While building devices from protein-based materials will improve biocompatibility, these new materials also bring unique challenges. The properties of gelatin can be tuned with the addition of several additives, crosslinkers, and plasticizers to improve mechanical properties while altering the characteristic fluid absorption and cell proliferation. Here, we discuss a variety of different gelatin actuators that allow for a range of actuation motions including swelling, bending, folding, and twisting, with various actuation stimulants such as solvent, temperature, pneumatic pressure, electric field, magnetic field, or light. In this review, we examine the fabrication methods and applications of such materials for building soft robots. We also highlight some ways to further extend the use of gelatin for biomedical actuators including using fiber-reinforced gelatin, gelatin cellular solids, and gelatin coatings. The understanding of the current state-of-the-art of gelatin actuators and the methods to expand their usage may expand the scope and opportunities for implantable devices using soft hydrogel robotics.