Abstract
Gastric cancer is a common tumor with high morbidity and mortality. MicroRNA (miRNA) can regulate gene expression at the translation level and various tumorigenesis processes, playing an important role in tumor occurrence and prognosis. This study aims to screen miRNA associated with gastric cancer prognosis as biomarkers and explore the regulatory genes and related signaling pathways. In this work, R language was used for the standardization and differential analysis of miRNA and mRNA expression profiles. Samples were randomly divided into a testing group and a training group. Subsequently, we built the five miRNAs (has-miR-9-3p, has-miR-135b-3p, has-miR-143-5p, has-miR-942-3p, has-miR-196-3p) prognostic modules, verified and evaluated their prediction ability by the Cox regression analysis. They can be used as an independent factor in the prognosis of gastric cancer. By predicting and analyzing potential biological functions of the miRNA target genes, this study found that the AR gene was not only a hub gene in the PPI network, but also associated with excessive survival of patients. In conclusion, this study demonstrated that hsa-miR-942-3p could be a potential prognostic marker of gastric cancer associated with the AR and MAPK/ERK signaling pathways. The results of this study provide insights into the occurrence and development of gastric cancer.
Subject
Microbiology (medical),Molecular Biology,General Medicine,Microbiology
Reference33 articles.
1. Treatment of gastric cancer
2. Lessons from common markers of tumor-initiating cells in solid cancers
3. MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma;Yang;PLoS ONE,2017
4. Regulation of miR-143-5p on cadmium-induced renal cell apoptosis and its mechanism;Chen;J. Nanjing Med. Univ. Nat. Sci. Ed.,2015
5. Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype;Ma;PLoS ONE,2012
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献