Abstract
SLU7 (Splicing factor synergistic lethal with U5 snRNA 7) was first identified as a splicing factor necessary for the correct selection of 3′ splice sites, strongly impacting on the diversity of gene transcripts in a cell. More recent studies have uncovered new and non-redundant roles of SLU7 as an integrative hub of different levels of gene expression regulation, including epigenetic DNA remodeling, modulation of transcription and protein stability. Here we review those findings, the multiple factors and mechanisms implicated as well as the cellular functions affected. For instance, SLU7 is essential to secure liver differentiation, genome integrity acting at different levels and a correct cell cycle progression. Accordingly, the aberrant expression of SLU7 could be associated with human diseases including cancer, although strikingly, it is an essential survival factor for cancer cells. Finally, we discuss the implications of SLU7 in pathophysiology, with particular emphasis on the progression of liver disease and its possible role as a therapeutic target in human cancer.
Funder
Instituto de Salud Carlos III
“Fondo Europeo de Desarrollo Regional”
Ministerio de Ciencia, Innovación y Universidades MICINN-Agencia Estatal de Investigación
AECC post-doctoral fellowship
Ministerio de Educación FPU fellowship
Ministerio de Educación FPI fellowship
Ramón y Cajal Program contract
Fundación Eugenio Rodríguez Pascual
Fundación Mario Losantos
Fundación M Torres
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference132 articles.
1. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. Molecular Biology of the Cell, 2003.
2. Buchberger, E., Reis, M., Lu, T.-H., and Posnien, N. Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Impli-cations for Evolutionary Studies. Genes, 2019. 10.
3. Mediator Roles Going Beyond Transcription;André;Trends Genet.,2020
4. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer;Baylin;Hum. Mol. Genet.,2001
5. Transcription;Deutschman;Crit. Care Med.,2005
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献