Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye

Author:

Maugeri GraziaORCID,D’Amico Agata Grazia,Magrì BenedettaORCID,Musumeci GiuseppeORCID,D’Agata VeliaORCID

Abstract

Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies. Activity-dependent neuroprotective protein (ADNP) is a protein involved in the physio-pathological processes of the eye. Noteworthy, is the small peptide derived from ADNP, known as NAP, which shows protective, antioxidant, and anti-apoptotic properties. Herein, we review the current state of knowledge concerning the role of ADNP in ocular pathologies, while providing an overview of eye anatomy.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference93 articles.

1. VIP, PACAP-38, BDNF and ADNP in NMDA-induced excitotoxicity in the rat retina;Teuchner;Acta Ophthalmol.,2011

2. Maugeri, G., D’Amico, A.G., Giunta, S., Giallongo, C., Tibullo, D., Bucolo, C., Saccone, S., Federico, C., Scollo, D., Longo, A., Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium. Antioxidants, 2022. 11.

3. Activity-dependent neurotrophic factor: Structure-activity relationships of femtomolar-acting peptides;Brenneman;J. Pharmacol. Exp. Ther.,1998

4. Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP;Zusev;Regul. Pept.,2004

5. International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide;Harmar;Pharmacol. Rev.,1998

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