Liver Brain Interactions: Focus on FGF21 a Systematic Review

Author:

Prida Eva,Álvarez-Delgado Sara,Pérez-Lois RaquelORCID,Soto-Tielas Mateo,Estany-Gestal Ana,Fernø Johan,Seoane Luisa MaríaORCID,Quiñones MarORCID,Al-Massadi OmarORCID

Abstract

Fibroblast growth factor 21 is a pleiotropic hormone secreted mainly by the liver in response to metabolic and nutritional challenges. Physiologically, fibroblast growth factor 21 plays a key role in mediating the metabolic responses to fasting or starvation and acts as an important regulator of energy homeostasis, glucose and lipid metabolism, and insulin sensitivity, in part by its direct action on the central nervous system. Accordingly, pharmacological recombinant fibroblast growth factor 21 therapies have been shown to counteract obesity and its related metabolic disorders in both rodents and nonhuman primates. In this systematic review, we discuss how fibroblast growth factor 21 regulates metabolism and its interactions with the central nervous system. In addition, we also state our vision for possible therapeutic uses of this hepatic-brain axis.

Funder

Instituto de Salud Carlos III

European Union

GAIN Proyectos de Excelencia

ISCIII

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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