Abstract
MicroRNAs are hidden players in complex psychophysical phenomena such as depression and anxiety related disorders though the activation and deactivation of multiple proteins in signaling cascades. Depression is classified as a mood disorder and described as feelings of sadness, loss, or anger that interfere with a person’s everyday activities. In this review, we have focused on exploration of the significant role of miRNAs in depression by affecting associated target proteins (cellular and synaptic) and their signaling pathways which can be controlled by the attachment of miRNAs at transcriptional and translational levels. Moreover, miRNAs have potential role as biomarkers and may help to cure depression through involvement and interactions with multiple pharmacological and physiological therapies. Taken together, miRNAs might be considered as promising novel therapy targets themselves and may interfere with currently available antidepressant treatments.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference265 articles.
1. Towards new approaches to disorders of fear and anxiety;Curr. Opin. Neurobiol.,2013
2. Australian Bureau of Statistics (2007). National Survey of Mental Health and Wellbeing: Summary of Results, Australian Bureau of Statistics.
3. Structure of anxiety and the anxiety disorders: A hierarchical model;J. Abnorm. Psychol.,1996
4. The descriptive epidemiology of commonly occurring mental disorders in the United States;Annu. Rev. Public Health,2008
5. Beebe, J.E. (2014). Youth at Risk: A Prevention Resource for Counselors, Teachers, & Parents, John Wiley & Sons.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献