Affiliation:
1. Institute of Urology and Clinical Oncology, Bashkir State Medical University, 450008 Ufa, Russia
Abstract
Bladder cancer (BLCA) is one of the most common types of malignant tumors of the urogenital system in adults. Globally, the incidence of BLCA is more than 500,000 new cases worldwide annually, and every year, the number of registered cases of BLCA increases noticeably. Currently, the diagnosis of BLCA is based on cystoscopy and cytological examination of urine and additional laboratory and instrumental studies. However, cystoscopy is an invasive study, and voided urine cytology has a low level of sensitivity, so there is a clear need to develop more reliable markers and test systems for detecting the disease with high sensitivity and specificity. Human body fluids (urine, serum, and plasma) are known to contain significant amounts of tumorigenic nucleic acids, circulating immune cells and proinflammatory mediators that can serve as noninvasive biomarkers, particularly useful for early cancer detection, follow-up of patients, and personalization of their treatment. The review describes the most significant advances in epigenetics of BLCA.
Funder
Bashkir State Medical University Strategic Academic Leadership Program
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference238 articles.
1. (2022, May 30). Bladder Cancer Statistics. Available online: https://www.wcrf.org/cancer-trends/bladder-cancer-statistics/.
2. Cancer statistics, 2018;Siegel;CA Cancer J. Clin.,2018
3. Tobacco smoke and bladder cancer-in the European prospective investigation into cancer and nutrition;Bjerregaard;Int. J. Cancer,2006
4. Bladder Cancer. Epidemiology, Diagnosis, and Management;Pashos;Cancer Pract.,2002
5. (2023, March 13). Key Statistics for Bladder Cancer. Available online: https://www.cancer.org/cancer/bladder-cancer/about/key-statistics.html.