Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression
Author:
Affiliation:
1. Department of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy
2. Department of Oncology, University of Torino, 10126 Torino, Italy
3. Department of Eye and Vision Science, University of Liverpool, Liverpool L7 8TX, UK
Abstract
Funder
Ministry of University and Research, Italy
Publisher
MDPI AG
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Link
https://www.mdpi.com/1422-0067/24/12/10232/pdf
Reference47 articles.
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2. Malaria-parasitized erythrocytes and hemozoin non-enzymatically generate large amounts of hydroxy fatty acids that inhibit monocyte functions;Schwarzer;Blood,2003
3. Monocyte recruitment during infection and inflammation;Shi;Nat. Rev. Immunol.,2011
4. The Rough Guide to Monocytes in Malaria Infection;Rogerson;Front. Immunol.,2018
5. Malaria pigment in leucocytes;Metzger;Trans. R. Soc. Trop. Med. Hyg.,1995
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